Take control over it.

Click here

to learn more about Naloxone Nasal Spray.

TAKING

CONTROL

Over it

WHAT IS NALOXONE
HYDROCHLORIDE NASAL SPRAY?

Amneal Naloxone Hydrochloride (Naloxone HCI) Nasal Spray, USP, 4mg is an FDA approved over-the-counter generic equivalent for Narcan® (Naloxone HCl) Nasal Spray.

Naloxone is a medication that has been widely used by emergency medical personnel and other first responders for decades to help reverse opioid overdose. It works by binding to opioid receptors and helping to reverse or block the effects of opioids, restoring normal breathing.

Naloxone is designed to rapidly reverse the effects of a life-threatening opioid emergency. It can restore normal breathing within 2 to 3 minutes in a person whose breath has slowed, or even stopped, as a result of a known or suspected overdose from opioids.

When using this product some people may experience symptoms when they wake up, such as shaking, sweating, nausea, or feeling angry. This is to be expected.

Naloxone is easy to carry and can be safely used, even if opioids are not present.

Research shows that higher dose and long-acting
naloxone have no added benefit revival rates and can result in more painful withdrawal symptoms for the person receiving Naloxone when compared to the 4mg dose.

Payne ER, Stancliff S, Rowe K, Christie JA, Dailey MW. Comparison of Administration of 8-Milligram and 4-Milligram Intranasal Naloxone by Law Enforcement During Response to Suspected Opioid Overdose — New York, March 2022–August 2023. MMWR Morb Mortal Wkly Rep 2024;73:110–113. DOI: http://dx.doi.org/10.15585/mmwr.mm7305a4

EASY

TO CARRY & SAFELY USE

RESTORES BREATHING IN

MINUTES

REVERSES

OPIOID OVERDOSE

FAQS

Naloxone HCl Nasal Spray 4mg is available over the counter. Therefore, anyone can carry it to administer on someone experiencing a known or suspected opioid overdose, potentially saving a life.

The Centers for Disease Control and Prevention (CDC) recommends that those at particularly high-risk should carry Naloxone Nasal Spray, including:5

  • People who are taking high-dose opioid medications (greater or equal to 50 morphine milligram equivalents per day) prescribed by a doctor
  • People who use opioids and benzodiazepines together
  • People who use unregulated opioids like heroin

Because you can’t use Naloxone Nasal Spray on yourself, always let others know you have it in case you experience an opioid overdose.5

You can use Naloxone Nasal Spray immediately if these signs or symptoms of an opioid overdose are present:5
  • Small, constricted “pinpoint pupils”
  • Falling asleep or losing consciousness
  • Slow, weak, or no breathing
  • Choking or gurgling sounds
  • Limp body
  • Cold and/or clammy skin
  • Discolored skin (especially in lips and nails)
Naloxone Nasal Spray is designed to be used without the need for any medical training. It won’t harm someone if they are not overdosing, or if they are overdosing on drugs other than opioids, so you can use it if you think someone is overdosing. To learn more about Naloxone Nasal Spray, including how to use it and possible side effects, visit Amneal’s Naloxone Nasal Spray product site.

Over 70% of preventable opioid deaths occur among those ages 25 to 54. Most of these victims are men, but the overdose rate among women is climbing.11

Black American Indian or Alaska Native communities are generally disproportionately affected by overdose due to economic inequities. [citation: Kariisa M, Davis NL, Kumar S, et al. Vital Signs: Drug Overdose Deaths, by Selected Sociodemographic and Social Determinants of Health Characteristics — 25 States and the District of Columbia, 2019–2020. MMWR Morb Mortal Wkly Rep 2022;71:940–947. DOI: http://dx.doi.org/10.15585/mmwr.mm7129e2.]

College-aged adults are the biggest users of prescription drugs for nonmedical purposes.12

  • Several factors may put one at higher risk of an opioid overdose, including:

    • Having an opioid use disorder
    • Injecting opioids
    • Starting to take opioids after a long period of abstinence (e.g., following detox or incarceration)
    • Using prescription opioids without the supervision of a healthcare provider
    • Taking high doses of opioids
    • Using opioids with alcohol and/or other medicines that suppress respiratory function
    • Having concurrent mental health conditions or medical conditions, such as HIV or liver or lung disease
    • Recreational use of…
      •  Synthetic opioids other than methadone, including fentanyl, fentanyl analogs, and tramadol
      • Heroin
      • Natural and semisynthetic opioids, including morphine, oxycodone, and hydrocodone
      • Methadone
      • Psychostimulants with abuse potential 

Naloxone Nasal Spray is designed to be used without the need for any medical training.

If you suspect an opioid overdose, administer Naloxone Nasal Spray according to the instructions and get emergency medical help right away. According to Substance Abuse and Mental Health Services Administration (SAMHSA), 

Take control over it.

Click here

to learn more about Naloxone Nasal Spray.

IN CRISIS? HELP IS AVAILABLE. SPEAK WITH SOMEONE TODAY.
SAMHSA National Helpline
If you or someone you know is struggling or in crisis, help is available. Call 1-800-662-4357 or text 988 or chat 988lifeline.org. You’ll be able to speak with a trained crisis counselor any time of day or night.

REFERENCES: 1. Council on Foreign Relations. (2023). Fentanyl and the U.S. Opioid Epidemic. [Backgrounder]. https://www.cfr.org/backgrounder/fentanyl-and-us-opioid-epidemic. Accessed September 2023. 2. Centers for Disease Control and Prevention. (2023) Frequently Asked Questions about Naloxone. Who Can Carry Naloxone? https://www.cdc.gov/stopoverdose/naloxone/faq.html. September 2023. 3. SAFEProject (Stop the Addiction Fatality Epidemic). State Naloxone Access Rules and Resources. https://www.safeproject.us/n loxone/awareness project/state-rules/. September 2023. 4. Centers for Disease Control and Prevention. Drug Overdose. SUDORS Dashboard: Fatal Overdose Data. (2022). Potential opportunities for intervention in 2021. https://www.cdc.gov/drugove dose/fatal/dashboard/index.h ml. February 2024. 5. Centers for Disease Control and Prevention. Reversing Opioid Overdoses with Lifesaving Naloxone. [Fact Sheet]. https://www.cdc.gov/stopove dose/naloxone/pdf/naloxone fact-sheet-508. pdf. September 2023. 6. NPR. (2023). In 2023 fentanyl overdoses ravaged the U.S. and fueled a new culture war fight. https://www.npr.org/2023/1 /28/1220881380/overdose fentanyl-drugs-addiction. Accessed February 2024. 7. American Psychiatric Association. (2022) Opioid Use Disorder. [Backgrounder]. https://www.psychiatry.org/p tients-families/opioid-use disorder. September 2023. 8. United States Drug Enforcement Administration. (2022). DEA Warns of Brightly-Colored Fentanyl Used to Target Young Americans. [Press Release]. https://www.dea.gov/press releases/2022/08/30/dea warns-brightly coloredfentanyl- used-target young-americans. September 2023. 9. National Institutes of Health. (2023). National Library of Medicine. National Center for Biotechnology Information. Opioid Addiction. [StatPearls]. https:// www.ncbi.nlm.nih.gov/books NBK448203/#:~:text=Introd ction-,Opioid%20use%20diso der%20and%20opioid%20add ction%20remain%20at%20ep demic%20levels,opioid%20us %20disorder%20(OUD). September 2023. 10. National Library of Medicine. National Center for Biotechnology Information. Campbell ND. Naloxone as a technology of solidarity: history of opioid overdose prevention. CMAJ. 2019 Aug 26;191(34):E945-E946. doi: 10.1503/cmaj.190257. PMID: 31451527; PMCID: PMC6710079. 11. National Safety Council. Injury Facts. Drug Overdoses. https://injuryfacts.nsc.org/h me-and-community/safety topics/ drugoverdoses/#:~:text=The 2035%2D%20to%2044%2Dy ar,and%20older%20is%20gr wing%20rapidly. September 2023. 12. Chibuzo Iloabuchi, BPharm; Eiman Aboaziza, MD; Xiaohui Zhao, MS, PhD; J. Douglas Thornton, PhD, PharmD, BCPS; Nilanjana Dwibedi, BPharm, MBA, PhD. (2021). “College Students’ Perceptions About Prescription Drug Misuse Among Peers”. American Health & Drug Benefits. Vol 14. No 1. file:///C:/ Users/ghall/Downloads/3 2021_college_students.pdf. September 2023. 

Images for reference only. Narcan® is a registered trademark of Emergent Operations Ireland Limited.
© 2024 Amneal Pharmaceuticals LLC. All rights reserved.

PP-NALOX-US-0003 11/2023